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Current advances for bone regeneration based on tissue engineering strategies
Rui Shi, Yuelong Huang, Chi Ma, Chengai Wu, Wei Tian
《医学前沿(英文)》 2019年 第13卷 第2期 页码 160-188 doi: 10.1007/s11684-018-0629-9
关键词: bone tissue engineering stem cell bone scaffold growth factor bone regeneration
Current progress on scaffolds of tissue engineering heart valves
DONG Nianguo, SHI Jiawei, CHEN Si, HONG Hao, HU Ping
《医学前沿(英文)》 2008年 第2卷 第3期 页码 229-234 doi: 10.1007/s11684-008-0043-9
Dongjiao ZHOU, Shaochuan SHEN, Junxian YUN, Kejian YAO, Dong-Qiang LIN
《化学科学与工程前沿(英文)》 2012年 第6卷 第3期 页码 339-347 doi: 10.1007/s11705-012-1209-1
关键词: cryogel scaffold tissue engineering dextran hyaluronate 3T3-L1 preadipocyte
Three-dimensional reconstruction of light microscopy image sections: present and future
null
《医学前沿(英文)》 2015年 第9卷 第1期 页码 30-45 doi: 10.1007/s11684-014-0337-z
Three-dimensional (3D) image reconstruction technologies can reveal previously hidden microstructures in human tissue. However, the lack of ideal, non-destructive cross-sectional imaging techniques is still a problem. Despite some drawbacks, histological sectioning remains one of the most powerful methods for accurate high-resolution representation of tissue structures. Computer technologies can produce 3D representations of interesting human tissue and organs that have been serial-sectioned, dyed or stained, imaged, and segmented for 3D visualization. 3D reconstruction also has great potential in the fields of tissue engineering and 3D printing. This article outlines the most common methods for 3D tissue section reconstruction. We describe the most important academic concepts in this field, and provide critical explanations and comparisons. We also note key steps in the reconstruction procedures, and highlight recent progress in the development of new reconstruction methods.
关键词: microtomy 3D imaging computer-assisted image processing 3D printing tissue scaffold
Vahideh R. Hokmabad, Soodabeh Davaran, Marziyeh Aghazadeh, Effat Alizadeh, Roya Salehi, Ali Ramazani
《化学科学与工程前沿(英文)》 2019年 第13卷 第1期 页码 108-119 doi: 10.1007/s11705-018-1742-7
Plants have been used for medicinal purposes for thousands of years but they are still finding new uses in modern times. For example, Elaeagnus angustifolia (EA) is a medicinal herb with antinociceptive, anti-inflammatory, antibacterial and antioxidant properties and it is widely used in the treatment of rheumatoid arthritis and osteoarthritis. EA extract was loaded onto poly(ϵ-caprolactone)-poly(ethylene glycol)-poly(ϵ-caprolactone) (PCL-PEG-PCL/EA) nanofibers and their potential applications for bone tissue engineering were studied. The morphology and chemical properties of the fibers were evaluated using Fourier transform infrared spectroscopy, field emission scanning electron microscopy, contact angle measurements and mechanical tests. All the samples had bead-free morphologies with average diameters ranging from 100 to 200 nm. The response of human cells to the PCL-PEG-PCL/EA nanofibers was evaluated using human dental pulp stem cells (hDPSCs). The hDPSCs had better adhesion and proliferation capacity on the EA loaded nanofibers than on the pristine PCL-PEG-PCL nanofibers. An alizarin red S assay and the alkaline phosphatase activity confirmed that the nanofibrous scaffolds induced osteoblastic performance in the hDPSCs. The quantitative real time polymerase chain reaction results confirmed that the EA loaded nanofibrous scaffolds had significantly upregulated gene expression correlating to osteogenic differentiation. These results suggest that PCL-PEG-PCL/EA nanofibers might have potential applications for bone tissue engineering.
关键词: Elaeagnus angustifolia scaffold electrospinning human dental pulp stem cell tissue engineering
Kan Wang, Chia-Che Ho, Chuck Zhang, Ben Wang
《工程(英文)》 2017年 第3卷 第5期 页码 653-662 doi: 10.1016/J.ENG.2017.05.013
医学模型或模具已广泛应用于医学培训和医患互动领域,同时也日益应用于手术规划、医学计算模型、算法核实和验证以及医疗器械的开发等方面。这种新应用需要高保真度、患者特异性及模拟组织结构的医学模具,其不仅能够模拟人体器官的几何结构,而且还具有器官的功能。随着三维(3D)打印和3D 生物打印技术的快速发展,许多研究人员已经开始使用增材制造技术来生产具有多种功能的医学模具。本文综述了3D 打印和3D 生物打印技术在制作功能性医学模具和生物结构方面的应用。特别讨论了3D 打印功能性医学模具(即组织模拟医学模具、放射性医学模具和生理医学模具)及被用于再生组织和器官的3D 生物打印模具的制备(即混合模式支架材料、可转换支架和集成传感器)工艺、发展现状以及未来发展趋势。
纤维基质——乳腺癌检测和治疗的新途径 Review
Rasha Rezk, Raquel Marín-García, Annica K.B.Gad
《工程(英文)》 2021年 第7卷 第10期 页码 1375-1380 doi: 10.1016/j.eng.2021.04.024
乳腺癌的特点是肿瘤细胞周围的蛋白纤维大量增加。这些纤维会提高组织的机械硬度,人们一直以来都是利用这一点并通过手动触诊来诊断肿瘤。最近的生物工程研究开发了新型生物材料,这些材料模拟了肿瘤微环境的力学特性和结构特性,可以用来了解这些特性如何调节乳腺癌的发展和扩散。本文概述了乳腺癌组织的力学特性与正常乳腺组织及非癌性病变组织的力学特性之间的差异,描述了生物材料模型是如何用于了解细胞外环境的硬度和黏度调节细胞迁移和乳腺癌转移的。此外,本文还强调了对生物材料模型的需求,这些模型可独立分析肿瘤微环境的单个和多个力学特性并利用肿瘤内不同区域的细胞,同时为进行乳腺癌转移新型机械疗法的开发提供了指导。
Atypical pituitary hormone–target tissue axis
《医学前沿(英文)》 2023年 第17卷 第1期 页码 1-17 doi: 10.1007/s11684-022-0973-7
关键词: thyroid-stimulating hormone follicle-stimulating hormone luteinizing hormone adrenocorticotrophic hormone prolactin
Progress and perspectives of neural tissue engineering
null
《医学前沿(英文)》 2015年 第9卷 第4期 页码 401-411 doi: 10.1007/s11684-015-0415-x
Traumatic injuries to the nervous system lead to a common clinical problem with a quite high incidence and affect the patient’s quality of life. Based on a major challenge not yet addressed by current therapeutic interventions for these diseases, a novel promising field of neural tissue engineering has emerged, grown, and attracted increasing interest. This review provides a brief summary of the recent progress in the field, especially in combination with the research experience of the author’s group. Several important aspects related to tissue engineered nerves, including the theory on their construction, translation into the clinic, improvements in fabrication technologies, and the formation of a regenerative environment, are delineated and discussed. Furthermore, potential research directions for the future development of neural tissue engineering are suggested.
The stem cell and tissue engineering research in Chinese ophthalmology
GE Jian, LIU Jingbo
《医学前沿(英文)》 2007年 第1卷 第1期 页码 6-10 doi: 10.1007/s11684-007-0002-x
关键词: available observable neuroregeneration protection function reconstruction
Decellularized extracellular matrix mediates tissue construction and regeneration
《医学前沿(英文)》 2022年 第16卷 第1期 页码 56-82 doi: 10.1007/s11684-021-0900-3
关键词: decellularized extracellular matrix 3D culture organoids tissue repair
Zhou-Fang XIONG MD, Wei-Hong DONG MD, Ze-Hua WANG MD,
《医学前沿(英文)》 2010年 第4卷 第1期 页码 112-116 doi: 10.1007/s11684-010-0016-7
关键词: cervical cancer radical surgery peritoneum subcutaneous tissue
Primary cilia in hard tissue development and diseases
《医学前沿(英文)》 2021年 第15卷 第5期 页码 657-678 doi: 10.1007/s11684-021-0829-6
关键词: primary cilia bone mechanical sensing hard tissue cilium-related bone disease tooth
Stem cell niches and endogenous electric fields in tissue repair
null
《医学前沿(英文)》 2011年 第5卷 第1期 页码 40-44 doi: 10.1007/s11684-011-0108-z
Adult stem cells are responsible for homeostasis and repair of many tissues. Endogenous adult stem cells reside in certain regions of organs, known as the stem cell niche, which is recognized to have an important role in regulating tissue maintenance and repair. In wound healing and tissue repair, stem cells are mobilized and recruited to the site of wound, and participate in the repair process. Many regulatory factors are involved in the stem cell-based repair process, including stem cell niches and endogenous wound electric fields, which are present at wound tissues and proved to be important in guiding wound healing. Here we briefly review the role of stem cell niches and endogenous electric fields in tissue repair, and hypothesize that endogenous electric fields become part of stem cell niche in the wound site.
Microorganism-derived biological macromolecules for tissue engineering
《医学前沿(英文)》 2022年 第16卷 第3期 页码 358-377 doi: 10.1007/s11684-021-0903-0
关键词: biological macromolecules regenerative medicine tissue engineering exopolysaccharide carbohydrate
标题 作者 时间 类型 操作
Current advances for bone regeneration based on tissue engineering strategies
Rui Shi, Yuelong Huang, Chi Ma, Chengai Wu, Wei Tian
期刊论文
Current progress on scaffolds of tissue engineering heart valves
DONG Nianguo, SHI Jiawei, CHEN Si, HONG Hao, HU Ping
期刊论文
Cryo-copolymerization preparation of dextran-hyaluronate based supermacroporous cryogel scaffolds for tissue
Dongjiao ZHOU, Shaochuan SHEN, Junxian YUN, Kejian YAO, Dong-Qiang LIN
期刊论文
Effect of incorporating Elaeagnus angustifolia extract in PCL-PEG-PCL nanofibers for bone tissue engineering
Vahideh R. Hokmabad, Soodabeh Davaran, Marziyeh Aghazadeh, Effat Alizadeh, Roya Salehi, Ali Ramazani
期刊论文
Non-closure of the peritoneum and subcutaneous tissue at radical hysterectomy: A randomized controlled
Zhou-Fang XIONG MD, Wei-Hong DONG MD, Ze-Hua WANG MD,
期刊论文